Lack of sleep linked to Alzheimer's
A lack of sleep could help toxic plaques develop in the brain, accelerating the progression of Alzheimer's disease.
David Holtzman looked at how sleep affected the levels of beta-amyloid protein in mice and humans. This protein causes plaques to build up in the brain, which some think cause Alzheimer's disease by killing cells.
Holtzman's group found that beta-amyloid levels were higher in mouse brains when the mice were awake than when they were sleeping. Lack of sleep also had an effect on plaque levels: when the mice were sleep-deprived – forced to stay awake for 20 hours of the day – they developed more plaques in their brains.
